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MDM2对手伊达萨努特林降低HDAC1/2丰富性和核心压缩伙伴,但不是HDAC3

Joshua P Smalley1, Shaun M Cowley2, James T Hodgkinson1

  • 1Leicester Institute of Structural and Chemical Biology, School of Chemistry, University of Leicester, Leicester LE1 7RH, United Kingdom.

ACS medicinal chemistry letters
|January 17, 2024
PubMed
概括

合成了针对HDAC1-3的新型PROTAC. 意想不到的是,单独使用的MDM2抑制剂伊达萨努特林降低了HDAC1/2水平,这表明MDM2 E3结合酶和HDAC1/2核心压缩复合体之间存在联系.

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