在坎比洛巴克特胃肠炎中对塞夫特里亚克森的耐药性
Megan D Hsu1, An Phuc D Ta1, Satori Iwamoto1
1College of Medicine, California Northstate University, Elk Grove, USA.
Cureus
|January 17, 2024
概括
坎比洛巴克特 (Campylobacter jejuni) 感染可能导致严重的腹. 从塞夫特里亚克松转换为勒沃素改善了患者的治疗结果,突出显示了对抗性感染需要考虑使用诺的必要性.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 坎比洛巴克菌感染在全球范围内很常见,在免疫功能低下的人群中引起胃肠炎和严重并发症.
- 传染性腹的标准治疗方法包括美트로尼达和金诺 (例如,西普罗撒,勒沃撒).
- 奎诺是有效的宽谱抗生素,可以对抗格兰氏阴性感染,包括Campylobacter jejuni (C. jejuni),但由于副作用和耐药性问题,它们不是第一线抗生素.
研究的目的:
- 报告一种由C. jejuni.引起的持续性传染性腹病例.
- 为了突出 ceftriaxone 的潜在无效性和levofloxacin 在治疗 C. jejuni 感染中的有效性.
- 强调根据治疗反应和已知的耐药性模式调整抗生素疗程的重要性.
主要方法:
- 一名患者出现了脑膜炎,肺炎和传染性腹的症状.
- 首次使用 ceftriaxone 治疗没有改善.
- 脑脊液 (CSF) 分析排除了脑膜炎;便研究发现了C. jejuni.
- 抗生素治疗方案被切换为levofloxacin,导致临床改善.
主要成果:
- 塞夫特里亚克松对患者的C. jejuni感染无效.
- 转换为levofloxacin导致患者病情显著改善.
- 该案例表明,C. jejuni. 在C. jejuni.中表现出对 ceftriaxone的耐药性.
结论:
- 持续的传染性腹对初始治疗没有反应,需要重新评估致病剂和抗生素治疗方案.
- 考虑切换到诸如利沃素之类的诺是非常重要的,因为当 ceftriaxone 对 C. jejuni.无效时.
- 这一案例强调了C. jejuni对 ceftriaxone耐药性的临床意义和诺的有用性.
更多相关视频
08:58Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
6.5K
05:34Author Spotlight: Development of an Enhanced Protocol for Rapid and Accurate Isolation of Campylobacter from Food Products
Published on: February 23, 2024
1.9K
相关概念视频
01:23Stringent Response in E. coli
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
01:30Development of Antibiotic Resistance
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
01:18Bacterial Gastroenteritis
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
01:25Mechanism of Antibiotic Resistance in MRSA
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
01:28Inhibitors of Bacterial DNA Synthesis
Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These antibiotics are selectively...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...