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三种益生菌的混合减轻了斯普拉格-道利 (SD) 鼠的洛帕胺诱导的便秘
Ye-Ji Jang1, Jin Seok Moon1, Ji Eun Kim1
1Research Laboratories at ILDONG Pharmaceutical Co., Ltd., Hwaseong 18449, Korea.
Food science of animal resources
|January 17, 2024
概括
益生菌混合物BIOVITA 3通过增强便输出和肠道运输,显著改善了大鼠的便秘. 这表明它作为一种功能性食品成分的潜力,可以缓解便秘.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 功能性食品 功能性食品
背景情况:
- BIOVITA 3是一种*Clostridium butyricum*,*Weizmannia coagulans*和*Bacillus subtilis*的益生菌混合物,用于肠道健康.
- 它在缓解便秘方面的有效性仍未得到研究.
研究的目的:
- 评估口服BIOVITA 3及其个别菌株对斯普拉格-道利大鼠的洛佩拉胺诱导的便秘的影响.
- 探索对肠道微生物群和短链脂肪酸生产的影响.
主要方法:
- 在Sprague-Dawley大鼠中使用loperamide诱导的便秘模型.
- 口服 BIOVITA 3 或单个益生菌菌株 (1.0×10^9 CFU/天).
- 分析包括便特征,胃肠道过渡,组织病理学,短链脂肪酸 (SCFA) 和转基因组学.
主要成果:
- 比奥维塔3显著改善了便数量,水含量和胃肠道过渡率.
- 组织病理学分析显示,BIOVITA 3组的粘膜层变厚.
- 所有益生菌治疗都增加了SCFA总量; BIOVITA 3显著改善了便秘大鼠的肠道微生物群多样性和丰富性.
结论:
- 在大鼠模型中,BIOVITA 3在缓解便秘方面显示出显著的功能益处.
- 这些发现支持BIOVITA 3作为功能性食品成分的潜在应用,以缓解便秘.
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