后急性COVID-19神经心理症状与正在进行的神经系统损伤无关
Maxime Taquet1,2, Zuzanna Skorniewska1, Henrik Zetterberg3,4,5,6,7,8
1Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK.
Brain communications
|January 17, 2024
概括
严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染后持续的神经精神症状与持续的神经系统损伤无关. 这项研究没有发现神经损伤标志物与COVID-19幸存者的长期认知或情绪缺陷之间的强烈关联.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 有相当数量的患者经历神经精神症状,包括认知缺陷,抑郁和焦虑,严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染后的几个月.
- 这些持续性症状的潜在机制在很大程度上是未知的.
- 虽然在急性COVID-19期间已经观察到神经系统损伤,但其在长期神经精神病学后果中的作用尚不清楚.
研究的目的:
- 调查正在进行的神经损伤是否有助于在严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 住院治疗的成年幸存者中观察到的持续或新出现的神经心理症状.
- 评估神经系统损伤标志物与急性COVID-19疾病的严重程度之间的关联.
- 评估这些生物标志物和神经精神症状在出院6个月和1年后之间的关系.
主要方法:
- 一项针对因严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 感染而住院的成年幸存者的前性队列研究.
- 在感染后6个月测量神经系统损伤和星细胞激活的血标志物 (神经纤维光,质纤维酸蛋白,总tau蛋白).
- 在出院6个月和1年后使用验证的问卷 (患者健康问卷,一般焦虑障碍,蒙特利尔认知评估,患者症状问卷) 评估神经精神症状.
主要成果:
- 在神经系统损伤的血标志物和急性COVID-19疾病的严重程度之间没有发现强有力的关联.
- 在住院时间和神经纤维光水平之间观察到一个小效应大小的关联.
- 重要的是,神经系统损伤标志物与急性后神经精神病症状的存在或严重程度在出院6个月和1年后之间没有发现显著的关联.
结论:
- 这些发现表明,严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染后持续的神经精神症状不太可能是由持续的神经损伤引起的.
- 这项研究提供了证据,证明可测量的神经损伤生物标志物与COVID-19幸存者的长期认知和情绪障碍之间的直接联系.
- 需要进一步的研究来阐明COVID-19后神经精神疾病背后的机制.
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