在慢性病中,肠免疫轴和心血管风险
Felix Behrens1,2,3,4, Hendrik Bartolomaeus2,3,5,6, Nicola Wilck2,3,5,6
1Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Clinical kidney journal
|January 17, 2024
概括
慢性病 (CKD) 患者因炎症而面临高心血管风险. 准肠道微生物群可能为减少心血管疾病 (CVD) 和改善CKD患者的生存率提供新的途径.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 微生物学 微生物学
背景情况:
- 患有慢性病 (CKD) 的患者经历了显著的心血管发病率和死亡率.
- 炎症越来越被认为是推动心血管疾病 (CVD) 在CKD进展的关键因素.
- 肠道微生物组在调节免疫和炎症方面的作用至关重要,在CKD中越来越重要.
研究的目的:
- 总结关于肠道微生物组失调,炎症和心血管疾病 (CVD) 在CKD中的相互作用的当前知识.
- 阐明由于CKD相关的微生物组变化导致细菌和宿主代谢的变化是如何导致心血管疾病的.
- 确定针对肠-免疫-心血管轴的潜在治疗策略,以管理CKD中的心血管疾病.
主要方法:
- 文献综述和近期研究成果的综合.
- 对调查CKD患者微生物组合的研究进行分析.
- 检查有关免疫反应和与CKD和肠道失调相关的代谢变化的研究.
主要成果:
- 慢性结核病与显著的肠道微生物组失调症有关.
- 失生症导致细菌和宿主新陈代谢的改变,促进全身炎症.
- 这种炎症是心血管疾病 (CVD) 发展和CKD进展的重要驱动因素.
结论:
- 肠道微生物群在CKD中通过免疫和代谢失调在心血管疾病的发病过程中发挥着关键作用.
- 针对肠-免疫-心血管轴是一个有前途的治疗途径.
- 旨在调节肠道微生物组的干预措施可以降低慢性病患者的心血管风险和死亡率.
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