肝脏和脏移植中的通用药物免疫抑制:现实世界的证据研究
Marco Finocchietti1, Maria Lucia Marino1, Alessandro C Rosa1
1Department of Epidemiology, Lazio Regional Health Service-ASL Roma 1, Rome, Italy.
Drug design, development and therapy
|January 17, 2024
概括
通用免疫抑制剂,如塔克罗利斯,环素和酸,在移植患者中提供与品牌药物相比的安全性和有效性. 它们越来越多的使用表明,在移植后的护理中,它们的接受度越来越高,并有可能大大节省成本.
科学领域:
- 移植免疫学 移植免疫学
- 药物经济学 药物经济学
- 药物使用研究研究药物使用研究.
背景情况:
- 免疫抑制剂对于预防脏和肝脏移植接受者的器官排斥至关重要.
- 通用免疫抑制剂的采用受到包括成本,疗效和安全感知的因素的影响.
- 了解通用免疫抑制剂的实际使用和影响对于医疗保健政策和患者管理至关重要.
研究的目的:
- 评估通用免疫抑制剂 (塔克罗利木斯,环素,菌酸盐) 与其品牌对应剂在和肝移植接受者的利用,益处风险概况和经济影响.
- 评估随着时间的推移,通用免疫抑制剂使用的趋势.
- 量化与通用免疫抑制剂使用相关的潜在成本节约.
主要方法:
- 一项回顾性,多中心的观察性研究,使用来自意大利四个地区的全国移植和区域医疗保健索赔数据.
- 2013年至2019年间发生的和肝移植患者的分析.
- 通过考克斯模型评估退院后30天内使用仿制药的情况,使用考克斯模型在两年内评估益处风险概况,并计算成本节省.
主要成果:
- 在移植接受者中,TACROLIMUS,cyclosporine和mycophenolate的仿制药使用量显著增加.
- 在通用和品牌免疫抑制剂配方之间观察到可比的风险益处概况.
- 潜在的每年成本节约约 2000 欧元,每人每治疗成分确定与通用使用.
结论:
- 越来越多的患者使用通用免疫抑制剂表明在移植社区内越来越多的接受.
- 塔克罗利斯,环素和美酸盐的通用配方显示出与品牌版本相比的风险益处概况.
- 通用免疫抑制剂吸收的显著区域和中心水平变异性需要进一步调查处方模式.
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