Jove
Visualize
联系我们

相关概念视频

Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Upstream Processing01:27

Upstream Processing

Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Microfluidic Nanobiosensor Detection of Botulinum Neurotoxin Serotype A.

ACS omega·2025
Same author

Combinatorial extracellular matrix tissue chips for optimizing mesenchymal stromal cell microenvironment and manufacturing.

NPJ Regenerative medicine·2025
Same author

On-chip human lymph node stromal network for evaluating dendritic cell and T-cell trafficking.

Biofabrication·2024
Same author

Advances in removing mass transport limitations for more physiologically relevant <i>in vitro</i> 3D cell constructs.

Biophysics reviews·2024
Same author

From animal testing to <i>in vitro</i> systems: advancing standardization in microphysiological systems.

Lab on a chip·2024
Same author

Characterizing On-Chip Angiogenesis Induction in a Microphysiological System as a Functional Measure of Mesenchymal Stromal Cell Bioactivity.

Advanced biology·2023
Same journal

Tunable self-assembling cellular microarray for single-neutrophil vital and suicidal extracellular traps.

Lab on a chip·2026
Same journal

Precise programmable tumor cell subpopulation sorting <i>via</i> an electromagnetic microfluidic platform.

Lab on a chip·2026
Same journal

Bridging dimensions: combining one- and two-photon 3D printing for microfluidic device fabrication.

Lab on a chip·2026
Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026
Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026
Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026
查看所有相关文章
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jun 27, 2026

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation
12:04

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

Published on: December 6, 2013

12.4K

在开发生物产品评估的微生理系统方面取得的进展.

Mona Mansouri1, Johnny Lam1, Kyung E Sung1

  • 1Cellular and Tissue Therapies Branch, Office of Cellular Therapy and Human Tissue, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA. kyung.sung@fda.hhs.gov.

Lab on a chip
|January 17, 2024
PubMed
概括
此摘要是机器生成的。

微生理系统 (MPS) 提供了测试医疗产品的新方法,特别是细胞和基因治疗等生物疗法. 本综述探讨了MPS在产品开发中更广泛使用的进步和挑战.

更多相关视频

Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells
08:15

Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells

Published on: September 28, 2018

11.0K
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

7.9K

相关实验视频

Last Updated: Jun 27, 2026

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation
12:04

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

Published on: December 6, 2013

12.4K
Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells
08:15

Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells

Published on: September 28, 2018

11.0K
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

7.9K

科学领域:

  • 生物医学工程 生物医学工程
  • 药物发现和开发 药物发现和开发
  • 再生医学是一种再生医学.

背景情况:

  • 微生理系统 (MPS) 或微型生理环境,在研究中模仿器官水平的功能.
  • MPS补充了传统方法,帮助医疗产品从临床前到市场阶段的进展.
  • 目前的MPS应用主要集中在药物发现上,在生物产品评估中使用有限.

研究的目的:

  • 审查用于评估生物产品的MPS技术进步.
  • 解决关于MPS用于细胞和基因疗法的研究缺口.
  • 讨论将MPS纳入主流产品测试中的挑战和考虑.

主要方法:

  • 关于MPS近期技术进步的文献综述.
  • 在生物产品评估中MPS应用的分析.
  • 讨论MPS翻译的挑战和未来方向.

主要成果:

  • 随着MPS技术的进步,显示了对生物产品评估的潜力.
  • 在使用MPS用于细胞和基因疗法方面需要更多的研究和开发.
  • 成功的翻译需要解决技术,监管和验证方面的挑战.

结论:

  • 在评估生物产品方面,MPS具有显著的前景,可以补充传统方法.
  • 进一步的研究和开发对于克服MPS在该领域采用的障碍至关重要.
  • 为了在产品测试和开发中广泛实施MPS,需要进行战略考虑.