肥胖和大动脉压力增加之间的反向关联在女性中减弱:Wakuya研究
Kaname Tagawa1,2, Yusuke Tsuru3, Katsumi Yokoi3
1Medical Center, Miyagi University of Education, Sendai.
Journal of hypertension
|January 17, 2024
概括
肥胖与较低的压力波反射有关,这是心血管事件的预测因素. 这种关联在女性中较弱,特别是在腹部肥胖患者中,这表明与身体脂肪分布相关的心血管风险的性别差异显著.
科学领域:
- 心血管生理学心血管生理学
- 肥胖问题研究研究
- 健康中的性别差异
背景情况:
- 压力波反射是一般人群心血管事件的关键指标.
- 肥胖通常与压力波反射有负面关联.
- 影响波反射的肥胖引起的动脉扩张在女性中比男性少.
研究的目的:
- 研究肥胖和压力波反射之间的关系中的性别差异.
- 为了分析一般和中心肥胖症对压力波反射的影响在性别之间如何不同.
主要方法:
- 在928名成年人中记录了度压力波形,以估计大动脉增大指数.
- 计算的身体质量指数 (BMI) 和测量的腰围作为肥胖指数.
- 对年龄,平均动脉压,糖尿病和高脂血症进行调整的分析.
主要成果:
- 大动脉增大指数在女性中明显高于男性.
- 无论是BMI还是腰围都与雄动脉增大指数负相关,无论是男性还是女性.
- 性别和腰围 (但不是BMI) 之间的显著相互作用影响了大动脉增大指数,表明中心肥胖症具有性别特异性的影响.
结论:
- 超重/肥胖对大动脉压力增加的抑制作用在女性中比男性少.
- 大动脉压力增大中的性别差异在患有中心 (腹部) 肥胖症的人群中比一般肥胖症更为明显.
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