从金属有机框架中对pH响应的eugenol按需释放,用于协同杀死细菌
Jing Wang1, Lin Li1, Xingyu Hu1
1School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, P.R. China. hujing@sit.edu.cn.
Dalton transactions (Cambridge, England : 2003)
|January 17, 2024
概括
一种新的金属有机框架 (MOF) 系统,Eu@B-UiO-66/Zn,充满了欧原醇和离子,显示了pH响应的受控释放和强大的协同抗菌活性对抗大肠杆菌和金黄色杆菌.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 细菌感染带来了重大的临床挑战,需要先进的抗菌策略.
- 金属有机框架 (MOF) 为药物输送和治疗应用提供了有前途的平台.
- 开发响应的抗菌系统对于有效的感染控制至关重要.
研究的目的:
- 开发一种基于MOF的新型协同抗菌系统 (Eu@B-UiO-66/Zn).
- 为了研究从MOF载体中控制释放的eugenol的pH响应.
- 评估开发的系统对常见的细菌病原体的协同抗菌疗效.
主要方法:
- 合成了一种层次性多孔MOF (B-UiO-66) 作为eugenol的载体.
- 复杂的欧原醇载荷MOF与双价离子一起形成Eu@B-UiO-66/Zn.
- 在不同的pH值 (5.8和8.0) 评估pH响应的尤根醇释放.
- 评估了对大肠杆菌 (大肠杆菌) 和金黄色葡萄球菌 (金黄色葡萄球菌) 的抗菌活性.
主要成果:
- Eu@B-UiO-66/Zn证明了对pH反应的欧原醇的受控释放,pH值在5.8时释放量显著增加 (80%),而pH值在8.0时则高出51%).
- 该系统表现出强大的协同抗菌作用,在24小时后实现了96.4%的对大肠杆菌和99.7%的对金黄色杆菌的抑制.
- Eu@B-UiO-66/Zn的抗菌功效优于自由欧原醇和未加载的MOF.
结论:
- 开发的Eu@B-UiO-66/Zn系统为响应性抗菌药物递送提供了一个有前途的战略.
- 欧原醇和离子的协同作用增强了抗菌功效.
- 这种基于MOF的方法有可能在未来应用于对抗细菌感染.
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