表面修饰对X射线光谱光子计数扫描仪/发光成像对比剂效率的影响:从基础研究到实体概念证明
Loic Cuau1, Pia Akl2,3, A Gautheron2,4
1Université de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, Laboratoire de Chimie, 46 allée d'Italie, F69364 Lyon, France. frederic.lerouge@ens-lyon.fr.
Nanoscale
|January 17, 2024
概括
研究人员开发了以化物为基础的纳米晶体,作为光谱光子计数CT (SPCCT) 和光学成像的多式对比剂. 这些新型纳米粒子为医学诊断提供了增强的成像能力.
科学领域:
- 纳米技术纳米技术
- 医疗成像医学成像
- 材料科学 材料科学 材料科学
背景情况:
- 射线成像是医学诊断的基石,不断的进步推动了对新型对比剂的需求.
- 像光谱光子计数CT (SPCCT) 和X射线发光光学成像等新兴技术需要开发先进的多式模式对比剂.
- 纳米粒子为创建可用于不同成像模式的对比剂提供了一个有希望的平台.
研究的目的:
- 设计和表征以兰化物为基础的纳米晶体作为多模式对比剂,用于同时进行SPCCT和光学成像.
- 为了研究兴奋剂度和表面修改对GdF3:Tb3+纳米晶体两种成像技术的性能的影响.
- 评估这些纳米晶体的生物相容性和体内疗效.
主要方法:
- 用 (Tb3+) 杂的加多化 (GdF3) 纳米晶体的合成和表征.
- 系统地改变Tb3+兴奋剂水平和表面修饰 (有机配体,涂层) 以优化性能.
- 在紫外线和X射线激发下评估发光特性.
- 使用微CT和SPCCT对比度生成的评估.
- 在体内使用SPCCT对裸体小鼠进行多式成像研究.
主要成果:
- 对光发和SPCCT对比度的最佳组合被确定为Gd0.9Tb0.1F3.3.
- 表面修改显著影响了发光强度和兴奋状态寿命,但没有改变SPCCT对比度.
- 在裸体小鼠中使用SPCCT与K边缘成像证明了成功的体内多式成像.
- 开发的纳米晶体显示出作为组合成像的生物相容剂的前景.
结论:
- 基于兰化物的GdF3:Tb3+纳米晶体是用于SPCCT和光学成像的有效多式对比剂.
- 表面工程可以调整发光特性,而不会影响X射线对比能力.
- 这些纳米晶体在开发用于增强医学成像的多功能对比剂方面取得了重大进展.
相关概念视频
Photoluminescence: Applications
402
Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
402
Super-resolution Fluorescence Microscopy
7.0K
Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
7.0K
X-ray Imaging
5.5K
German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
5.5K
Variables Affecting Phosphorescence and Fluorescence
504
Fluorescence and phosphorescence are essential phenomena in fields like analytical chemistry, biological imaging, and materials science, where they detect molecular properties and visualize cellular structures. Understanding the variables that influence these luminescent behaviors is crucial for maximizing accuracy and efficiency in their applications. These variables can broadly be grouped into chemical structure, solvent properties, and external conditions, each playing a distinct role in...
504


