轻度认知障碍的计算机认知训练:非洲裔美国人和高加索人的发现
1Adaora Nwosu, Neurocognitive Disorders Program, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA, adaora.nwosu@duke.edu.
The journal of prevention of Alzheimer's disease
|January 17, 2024
概括
基于网络的认知训练可能会使非洲裔美国人轻度认知障碍 (MCI) 与白人一样受益. 需要对阿尔茨海默病预防试验中代表性不足的群体进行进一步的研究.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 临床试验 临床试验
背景情况:
- 患有轻度认知障碍 (MCI) 的非裔美国人可能面临比白人更高的痴呆风险.
- 种族对MCI患者认知训练有效性的影响尚不清楚.
研究的目的:
- 研究种族对MCI个体认知训练结果的影响.
- 为了比较密集的,基于家庭的计算机培训与基于网络的游戏或跨种族群体的十字词拼图的有效性.
主要方法:
- 利用了78周的数据,两站随机试验涉及105名参与者 (22.8%的非洲裔美国人).
- 评估了认知和功能尺度的变化,并通过MRI测量了海马体积和皮层厚度.
- 在这项探索性研究中,使用了经过调整以基线得分的线性模型.
主要成果:
- 种族对ADAS-Cog-11分数或MRI结果没有显著的影响.
- 与白人参与者相比,非洲裔美国参与者在第52周和第78周的功能活动问卷 (FAQ) 得分显著改善.
- 这种改善在计算机化认知训练 (CCT) 队列中尤为明显.
结论:
- 基于网络的认知训练可能为患有MCI的非洲裔美国人和白人提供类似的好处.
- 强调需要在阿尔茨海默病预防研究中包括代表性不足的少数群体.
- 初步发现支持进一步研究针对不同人群量身定制的认知干预措施.
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