关于急性髓性白血病缓解期的维持治疗的考虑
Gary J Schiller1, Vlad Kustanovich2
1Hematological Malignancy/Stem Cell Transplant Program, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Expert review of anticancer therapy
|January 17, 2024
概括
维持疗法,特别是低剂量治疗,在初始缓解或全移植后,对患有急性髓性白血病的成年患者预防复发有希望. 建议对向和免疫疗法的进一步研究.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床研究 临床研究
背景情况:
- 在成人急性髓性白血病 (AML) 中,复发很常见,即使在第一个完全缓解的整合性全移植后,也很常见,影响20%-40%的患者.
- 识别可能受益于针对残留疾病的治疗方法的患者对于预防复发至关重要.
结论:
- 虽然随机研究结果有限,但建议在不同的缓解后管理场景中进行维持治疗.
- 未来的研究应该集中在免疫疗法和AML风险不可知干预的随机研究上.
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