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Updated: Jul 5, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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作为双重抗增殖EGFR/CDK2抑制剂的新型罗利丁-碳胺衍生物

Frias Obaid Arhema Frejat1,2,3, Bingbing Zhao1,2, Nooruldeen Furaijit4

  • 1School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, PR China.

Chemical biology & drug design
|January 17, 2024
PubMed
概括

研究人员开发了新的pyrrolidine-carboxamide衍生物作为潜在的癌症治疗方法. 化合物7g显示出强大的抗增殖活性,在几种癌细胞系中表现优于多克索鲁比辛,并抑制了关键的癌症相关酶.

关键词:
在CDK中,CDK就是CDK.欧洲农业基金会 (EGFR) 是一个基金.这是一种抗增殖药物.卡尔博克萨米德 (Carboxamide) 是一种碳酸盐.皮罗利丁胺是什么?公司的可行性,可行性.

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