美国患有未经2L干细胞移植治疗的扩散性大B细胞淋巴瘤的患者的治疗模式和费用
Teofilia Acheampong1, Tao Gu1, Trong Kim Le1
1Bristol Myers Squibb, 3401 Princeton Pike, Lawrenceville, NJ 08648, USA.
Future oncology (London, England)
|January 17, 2024
概括
不接受干细胞移植的扩散性大B细胞淋巴瘤 (DLBCL) 患者承担了大量的医疗费用和资源使用,主要来自住院治疗. 需要新的治疗方法来减少这种临床和经济负担.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 卫生经济学 卫生经济学
背景情况:
- 扩散性大B细胞淋巴瘤 (DLBCL) 是一种常见的非霍奇金淋巴瘤.
- 治疗模式和相关的医疗资源利用率 (HCRU) 以及在二线环境中不接受干细胞移植的患者的成本需要进一步描述.
研究的目的:
- 评估在第二线设置中没有接受干细胞移植的DLBCL患者的治疗模式,HCRU和成本.
- 确定这一患者群体中医疗保健支出的主要驱动因素.
主要方法:
- 从2009年1月1日到2020年9月30日,对行政索赔数据库 (MarketScan®) 的回顾性分析.
- 包括DLBCL患者,重点是那些没有接受干细胞移植的患者在二线治疗中.
主要成果:
- 大多数750名患者在一线治疗中 (86.8%) 接受了瑞图西马布加上环胺,多克索鲁比辛,温克里斯和普雷迪尼松.
- 第二线治疗包括修复剂 (39.5%) 或bendamustine ±修复剂 ±其他 (16.3%).
- 超过一半的患者住院 (平均持续时间为16.5天/患者/年),平均年度医疗/药房费用为141,532美元,主要是由DLBCL相关索赔推动的.
结论:
- 在DLBCL患者中,医疗保健资源的利用和成本是相当大的,主要是由于住院和门诊访问.
- 显然需要创新的治疗策略来减轻与DLBCL管理相关的临床和经济负担.
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