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人类大脑中C-乳酸盐氧化的证据来自超极化C-MRI
Biranavan Uthayakumar1,2, Hany Soliman3, Albert P Chen4
1Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Magnetic resonance in medicine
|January 17, 2024
概括
乳酸氧化显著影响人类大脑中的二碳酸盐信号. 超极化碳-13MRI显示,降低乳酸盐水平降低了二碳酸盐信号,证实了乳酸盐的存在.
科学领域:
- 神经成像是一种神经成像.
- 代谢成像 - 代谢成像
- 生物化学 生物化学
背景情况:
- 大脑中的二碳酸盐信号对于理解神经元代谢至关重要.
- 超极化碳-13 (13C) 核磁共振 (MRI) 是一种非侵入性方法,可以在体内研究大脑新陈代谢.
研究的目的:
- 研究乳酸氧化对人类清醒大脑中13C二碳酸盐信号的贡献.
- 为了测试乳酸在大脑中转化为二碳酸盐的假设.
主要方法:
- 在6名健康志愿者中利用过极化13C-MRI.
- 在扫描过程中通过射频和操纵13C-乳酸盐水平.
- 在132个大脑区域进行了13C-乳酸盐,13C-二碳酸盐和13C-酸盐信号的比较.
主要成果:
- 增加13C-乳酸盐的射频和导致13C-二碳酸盐信号显著下降 (p=0.04).
- 在大多数研究的大脑区域中观察到这种二碳酸盐信号的减少.
结论:
- 这项研究表明,乳酸氧化有助于人类大脑中观察到的13C二碳酸盐信号.
- 研究结果证实,注射的13C-pyruvate转化为13C-乳酸盐,然后再氧化为13C-pyruvate,随后再氧化为二碳酸盐.
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