在使用CarpediemTM系统的新生儿连续替代疗法中,清除和营养
Kim T Vuong1, Molly R Vega2, Lauren Casey2
1Division of Pediatric Nephrology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA. ktvuong@texaschildrens.org.
Pediatric nephrology (Berlin, Germany)
|January 17, 2024
概括
接受连续脏替代疗法 (CKRT) 的患有功能衰竭的婴儿表现出改善的营养供应,但增长延迟. 卡尔佩迪姆TM装置促进了安全过渡到腹腔透析,突出了在新生儿透析期间需要优化生长策略的需要.
科学领域:
- 儿科脏病学 儿科脏病学
- 新生儿重症监护中心新生儿重症监护中心
- 脏替代疗法治疗 脏替代疗法
背景情况:
- 患有功能衰竭 (KF) 的婴儿因流体和蛋白质限制而经历生长障碍.
- 在持续置换疗法 (CKRT) 期间优化营养供应对重症婴儿来说是个挑战.
- 心脏-脏,儿科透析紧急机器 (CarpediemTM) 为新生儿CKRT提供了一个潜在的解决方案.
研究的目的:
- 通过使用CarpediemTM设备分析KF接受CKRT的婴儿的分娩营养和生长.
- 评估CarpediemTM作为通往腹腔透析 (PD) 的桥梁的安全性和有效性.
主要方法:
- 在 CarpediemTM CKRT 上对婴儿进行单中心观察性研究.
- 收集有关电路特征,营养供应,人类学和疾病严重程度的数据.
- 计算了正常化蛋白外观 (nPNA) 作为蛋白质代谢的替代物.
主要成果:
- 八名婴儿接受了CKRT,平均时间为31.9天,主要是区域酸盐抗凝药.
- 在CKRT期间,营养摄入量 (体积,蛋白质,卡路里) 和nPNA增加.
- 14天后观察到体重增加,但目标体重和生长速度在CKRT后延迟了6个月.
结论:
- 卡佩迪姆TM是一种安全有效的桥梁,用于新生儿KF的PD.
- 接受CKRT的婴儿经历了延迟的生长速度,尽管有足够的营养支持.
- 需要进一步的研究来优化新生儿透析中的生长策略.
相关概念视频
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
162
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
162
01:27Dialysis
319
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
319
01:23Renal Clearance
949
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
949
01:17Factors Affecting Renal Clearance: Renal Impairment
95
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
95
01:08Renal Drug Clearance: Comparison Between Renal Excretion Methods
137
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
137
01:07Determination of Renal Drug Clearance: Graphical and Midpoint Methods
125
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
125