胎儿大脑发育在怀孕中复杂的妊娠糖尿病
Maria Chiara Marra1, Ilenia Mappa1, Maria Elena Pietrolucci1
1Department of Obstetrics and Gynecology, Fondazione Policlinico Tor Vergata, Università di Roma Tor Vergata, Roma, Italy.
Journal of perinatal medicine
|January 17, 2024
概括
孕期糖尿病 (GDM) 影响胎儿大脑发育,特别是乳腺的生长. 针对GDM的孕产妇胰岛素治疗对胎儿大脑结构 (如大脑体和裂) 产生了更明显的影响.
科学领域:
- 神经科学是一个神经科学.
- 产科 产科 产科 产科 产科
- 发展生物学 发展生物学
背景情况:
- 孕期糖尿病 (GDM) 与后代的神经认知障碍有关.
- 孕产妇高血糖对胎儿大脑发育的确切影响需要进一步阐明.
研究的目的:
- 为了评估由GDM复杂的怀孕中胎儿大脑和的发育.
- 评估GDM对特定胎儿大脑结构和皮层发育的影响.
主要方法:
- 100个GDM怀孕和100个对照对象的前性观察研究.
- 在怀孕29-34周的神经声学测量大脑体 (CC),小脑体 (CV),西尔维亚 (SF),围骨 (POF) 和骨裂 (CF).
- 基于GDM治疗 (饮食与胰岛素治疗) 的子组分析.
主要成果:
- 接受胰岛素治疗的GDM母亲的胎儿与对照组和饮食治疗的GDM相比,CC较小.
- 对头周长进行校正的脑小虫深度在GDM (饮食和胰岛素治疗) 的胎儿中较小,而不是对照组.
- 在母亲GDM的胎儿中,Sylvian, parieto-occipital和calcarine裂显着较小,在需要胰岛素的胎儿中,减少更为明显.
结论:
- 在GDM怀孕中,胎儿大脑生长和皮层发育模式发生变化.
- 这些神经发育变化在需要胰岛素治疗以治疗GDM的母亲的胎儿中更为明显.
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