丸激素治疗和男性的骨折 带有阴性腺的男性
Peter J Snyder1, Douglas C Bauer1, Susan S Ellenberg1
1From the Perelman School of Medicine, University of Pennsylvania, Philadelphia (P.J.S., S.S.E.); the San Francisco Coordinating Center, University of California, San Francisco, San Francisco (D.C.B.); the University of Pittsburgh Graduate School of Public Health, Pittsburgh (J.A.C.); the University of Wisconsin Statistical Data Analysis Center, Madison (K.A.B.); Brigham and Women's Hospital, Harvard Medical School, Boston (S.B.); AbbVie, North Chicago, IL (M.G.M., N.S.K., X.L.); and the Cleveland Clinic Coordinating Center for Clinical Research, Cleveland Clinic, Cleveland (S.E.N.).
治疗低阴性恋症并没有降低老年男性的骨折风险. 该研究发现,与安慰剂相比,在接受丸激素的男性中,骨折的发生率在数值上更高.
科学领域:
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
- 骨健康 骨健康 骨健康
背景情况:
- 众所周知,替代疗法 (TRT) 可以改善男性的骨密度.
- 然而,需要进行大规模的长期研究来证实TRT对骨折发生率的影响.
研究的目的:
- 为了评估与安慰剂相比,接受丸激素治疗的中年和老年男性的临床骨折风险.
- 这项研究是TRAVERSE试验的分试验,评估心血管安全性.
主要方法:
- 这是一项双盲,随机,安慰剂控制的试验,涉及5204名45-80岁的男性,他们患有阴道腺缩症和心血管风险.
- 参与者每天接受丸激素或安慰剂凝,骨折事件通过医疗记录来判断.
主要成果:
- 经过3.19年的中位随访后,丸组的3.50%发生了临床骨折,而安慰剂组的2.46% (HR,1.43;95% CI,1.04-1.97).
- 在丸激素组的所有骨折终点中,骨折发生率在数值上更高.
结论:
- 与安慰剂相比,中年和老年男性的治疗并没有减少临床骨折的发生率.
- 在接受丸激素治疗的男性中,观察到数量上更高的骨折发生率.
更多相关视频
07:25A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
07:12Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
相关概念视频
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Testosterone: Functions and Regulation
Infertility in Males
Bone Remodeling
