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在例行婴儿健康检查期间使用阿齐思罗米辛,以防止死亡

Ali Sié¹, Mamadou Ouattara¹, Mamadou Bountogo¹

¹From Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso (A.S., M.O., M.B., V.B., T.O., G.C., C.D., C.B.); and the Francis I. Proctor Foundation (E.L., H.H., T.C.P., B.F.A., T.M.L., C.E.O., J.R.), the Department of Epidemiology and Biostatistics (T.C.P., T.M.L., C.E.O.), the Department of Ophthalmology (T.C.P., B.F.A., T.M.L., C.E.O.), and the Institute for Global Health Sciences (T.M.L., C.E.O.), University of California, San Francisco, San Francisco.

The New England journal of medicine

|January 17, 2024

概括

在布基纳法索,给婴儿服用亚齐思罗米并没有防止婴儿死亡. 这项研究发现,当在例行医疗检查期间给予阿齐思罗米时,婴儿死亡率没有降低.

科学领域:

全球健康全球健康
儿科儿科儿科
传染性疾病传染性疾病

背景情况:

在非洲一些地区,大规模的阿齐思罗米辛分发减少了儿童死亡率,特别是在12个月以下的婴儿中.
在预防婴儿死亡方面,针对阿兹罗米辛的常规婴儿医疗保健访问的有效性尚不清楚.

研究的目的:

为了评估在婴儿期 (5-12周) 通过例行医疗保健检查给出的单剂量阿齐思罗米在预防6个月前死亡方面的疗效.
评估婴儿阿齐思罗米对布基纳法索全因死亡率的影响.

主要方法:

一个随机的,安慰剂控制的试验,涉及32877名婴儿在布基纳法索.
婴儿在例行医疗检查期间接受单剂阿齐思罗米 (20毫克/公斤) 或安慰剂.
主要终点是6个月前的死亡率,在6个月后评估生命状况.

主要成果:

在6个月前,在阿兹罗密辛组 (82例死亡) 和安慰剂组 (75例死亡) 之间没有观察到死亡率的显著差异.
死亡风险比为1.09 (95% CI,0.80至1.49),预先指定的子组中没有发现统计学上显著的影响.
两组之间没有发现不良事件的差异.

结论:

通过布基纳法索现有的医疗保健系统向婴儿注射亚齐思罗米并没有防止死亡.
研究结果表明,在这种情况下,这种特殊的干预策略在降低婴儿死亡率方面并不有效.

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