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灰蓝香草乙醇提取物的低压和内皮依赖性血管松作用在老鼠中

Sujin Shin¹, Junkyu Park², Ho-Young Choi³

¹Department of Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.

Foods (Basel, Switzerland)

|January 17, 2024

概括

灰蓝色香料 (GS) 乙醇提取物 (GSE) 在高血压大鼠中显著降低了血压. 此外,GSE还表现出依赖内皮的血管松作用,这表明对管理高血压的潜力.

科学领域:

药理学药理学是指药理学的学科.
心血管研究研究心血管研究
自然产品化学自然产品化学

背景情况:

高血压是一个全球性的健康问题,患病率正在增加.
林德拉格劳卡 (灰蓝色香料) 传统上使用,但缺乏对心血管影响的科学验证.
关于Lindera glauca的低血压和血管松性质的研究有限.

研究的目的:

研究灰蓝色香料乙醇提取物 (GSE) 对自发高血压大鼠 (SHRs) 的低血压作用.
为了评估GSE对隔离的老鼠胸前动脉的血管松作用.
探索GSE血管松活性的潜在机制.

主要方法:

用GS分支 (GSE) 的乙醇提取物给了15周大的SHRs.
血压测量使用尾巴袖子方法4个小时后给药.
血管松剂的作用被评估在孤立的Sprague-Dawley大鼠胸前大动脉环上,使用不同的GSE度.
研究了涉及K+通道的机制和对血管新素II诱导的收缩的影响.

主要成果:

在SHR中,GSE的使用 (1000 mg/kg) 显著降低了静缩和静缩血压.
GSE在老鼠大动脉环上表现出剂量依赖,内皮依赖的血管松作用.
GSE的血管松活性涉及向内调整器,电压依赖和非选择性的K+通道.
GSE抑制的血管酶II诱导的大动脉环收缩.

结论:

GSE具有显著的低血压和血管松性质.
血管松作用依赖于内皮,并通过K+通道调节进行介导.
GSE显示出作为管理和预防高血压的功能性食物的潜力.
需要进一步的研究来确定活性成分和安全评估.

关键词:

林德拉格劳卡 (Lindera glauca) 是一种葡萄树.通过NO/cGMP途径.ангиотензин II 的使用血压血压血压血压它们是内皮细胞的内皮细胞.灰色蓝色的香料灌木这种高血压,高血压.自发高血压的老鼠.血管放松剂血管放松剂

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