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基于天然和合成生物材料的微型和纳米药物输送系统的最新进展
Md Harun-Or-Rashid1, Most Nazmin Aktar1, Md Sabbir Hossain2
1Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji 671-2280, Hyogo, Japan.
Polymers
|January 17, 2024
概括
聚合物药物输送使用先进的可生物降解聚合物来增强细胞吸收. 本次审查涵盖了天然和合成聚合物,包括树枝状聚合物,用于创新的药物和基因传递系统.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 制药科学 制药科学
背景情况:
- 聚合物药物输送已经显著进步,使药物成分更容易进入细胞.
- 创新策略采用可生物降解和可生物降解的聚合物,其中天然聚合物如酸盐和合成聚合物如聚乳酸是关键.
- 研究正在探索仿生系统,无药物宏分子疗法,以及各种天然和合成生物材料的临床应用.
研究的目的:
- 审查聚合物药物输送技术的进展.
- 讨论药物输送系统中使用的各种天然和合成聚合物.
- 突出结合合成和生物方法的潜力,用于革命性的药物和基因传递装置.
主要方法:
- 对聚合物药物输送系统的文献综述.
- 对自然聚合物的分析 (氨酸,奇托桑,德克斯特林,多糖化物,多糖酸,多乳酸,氨酸).
- 研究合成聚合物 (聚二乙基甲酸),聚N-异烯酸胺,聚乙胺,树突聚合物,可生物降解聚合物,可生物吸收聚合物) 和它们的应用.
主要成果:
- 聚合物系统,包括生物相容的共聚物和树枝状物,在治疗癌症等疾病方面表现有前途.
- 天然和合成聚合物在制药行业越来越多地用于药物输送.
- 通过整合合成和生物方法创建的微型和纳米药物输送系统,提供了革命性的治疗潜力.
结论:
- 聚合物药物输送是一个快速发展的领域,具有多样化的应用.
- 自然和合成聚合物的组合,以及先进的系统设计,对于未来的治疗创新至关重要.
- 对这些综合方法的进一步研究有望在药物和基因输送装置方面取得突破性进展.
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