糖尿病患者和非糖尿病肥胖患者之间的代谢签名:系统审查协议
Yuxing Tai1, Xiaoqian Yang2, Xiaochao Gang1
1Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, China.
PloS one
|January 17, 2024
概括
本系统性审查协议确定了肥胖个体2型糖尿病 (T2DM) 的代谢生物标志物. 它旨在通过分析代谢途径,找到预防和治疗T2DM的新方法.
科学领域:
- 代谢学 代谢学 代谢学
- 生物标志物发现发现
- 系统审查方法论 系统审查方法论
背景情况:
- 2型糖尿病 (T2DM) 是一种慢性疾病,其特征是高血糖.
- 体重指数 (BMI) 较高的肥胖症是T2DM发展的重要危险因素.
- 在肥胖个体中识别特定的代谢物生物标志物对于早期T2DM检测至关重要.
研究的目的:
- 系统地审查和识别与肥胖患者T2DM相关的代谢物生物标志物.
- 在肥胖的背景下,探索涉及T2DM发展的潜在代谢途径.
- 在肥胖人群中建立T2DM新型预防和治疗策略的基础.
主要方法:
- 一个在PROSPERO (CRD42023405518) 中注册的系统审查协议.
- 在EMBASE,PubMed和Web of Science数据库中进行文献搜索 (开始至2023年12月).
- 数据提取包括参与者特征,分析平台,代谢物变化和使用MetaboAnalyst 5.0与KEGG和HMDB数据库的途径分析.
主要成果:
- 结果将在同行评审期刊上发表,详细介绍已识别的代谢物生物标志物及其相关的代谢途径.
- 该审查将提供关于肥胖个体T2DM代谢生物标志物的当前证据的全面摘要.
结论:
- 这一系统性审查将总结潜在的生物标志物和代谢途径,与肥胖患者的T2DM相关.
- 结果将作为未来研究和T2DM预防和治疗的临床应用的参考.
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