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酒精消费与萨尔科佩尼亚风险的关联:剂量反应元分析
Yun-Ling Bu1, Cao Wang1, Can Zhao1
1Department of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
The American journal of drug and alcohol abuse
|January 17, 2024
概括
这次元分析没有发现酒精消费与肉症风险之间的总体联系. 然而,适度饮酒在男性中显示出潜在的保护作用,这需要谨慎的解释.
科学领域:
- 老年学是指老年学的学科.
- 营养流行病学 营养流行病学
- 公共卫生 公共卫生
背景情况:
- 标志着与年龄相关的肌肉质量和力量损失的萨尔科佩尼亚与饮酒有着有争议的关联.
- 现有的关于酒精对萨尔科佩尼亚风险的影响的研究提出了相互矛盾的发现.
- 了解这种关系对于公共卫生和衰老研究至关重要.
研究的目的:
- 进行全面的元分析,评估酒精消费与患上皮症的风险之间的关联.
- 综合来自多项研究的证据,以更好地理解这种关系.
- 探索潜在的性别差异和剂量反应模式.
主要方法:
- 在主要数据库 (PubMed,Embase,Cochrane,Web of Science等) 进行系统的文献搜索. 没有语言限制,直到2023年9月20日.
- 从62项涉及454,643名参与者的研究中,对95%置信区间 (CI) 的合并概率比率 (OR) 的元分析.
- 亚组分析和非线性剂量反应分析,以调查特定的因素和模式.
主要成果:
- 总的来说,酒精消费与肉类的存在没有显著关联 (合并OR=0.964,95%CI=0.912-1.019).
- 亚组分析显示,在饮酒的男性中,肉类的风险降低 (OR = 0.763,95% CI = 0.622-0.938).
- 观察到一个J形的关联,最低的风险约为每天6.6克的酒精 (OR = 0.765,95%CI = 0.608-0.957).
结论:
- 酒精消费并未被确定为萨科佩尼亚发展的一般风险因素.
- 在一些分析中,特别是在男性中,建议的潜在保护作用需要谨慎解释,因为总体上是零发现.
- 需要进一步的研究,以澄清酒精摄入量和肉症的复杂关系和潜在细微差别.
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