2023年关于HUPO人类蛋白质组项目的蛋白质组的报告
Gilbert S Omenn1,2, Lydie Lane3, Christopher M Overall4,5
1University of Michigan, Ann Arbor, Michigan 48109, United States.
Journal of proteome research
|January 17, 2024
概括
人类蛋白质组项目使用质谱和其他方法确定了93%的人类蛋白质. 这一重大进展推动了蛋白质组学在健康和疾病研究的多组学研究中的整合.
科学领域:
- 蛋白质组学和人类生物学
- 多种经济学和系统生物学
- 生物医学研究生物医学研究
背景情况:
- 人类蛋白质组项目 (HPP) 旨在识别所有人类蛋白质,并将蛋白质组学纳入多组学研究中.
- 国际合作,数据共享和标准化分析是HPP的关键组成部分.
- 通过PeptideAtlas,MassIVE-KB,neXtProt和人类蛋白质图表来保持质量保证.
研究的目的:
- 报告人类蛋白质组部分列表识别的当前状态.
- 突出蛋白质组学与健康和疾病研究中的其他组学平台的整合.
- 概述向一个专注于蛋白质功能的大挑战项目的过渡.
主要方法:
- 质谱学 (MS) 数据集的标准化再分析.
- 综合和治愈MS和非MS蛋白质数据.
- 广泛的抗体分析和蛋白质检测方法.
主要成果:
- 在19,778个预测的人类蛋白中,可信检测 (PE1) 了18,397个 (93%).
- 17,453个PE1蛋白通过MS确定,944个通过非MS方法.
- 还有1381种蛋白质尚未确定 (PE2-PE4),一些条目正在进行重新分类.
结论:
- 在构建人类蛋白质组部分列表方面取得了显著进展.
- 蛋白质组学越来越多地被整合到健康和疾病的多组学研究中.
- 该HPP准备着专注于确定生物网络和途径中的蛋白质功能.
关键词:
生物学和疾病-HPP (B/D-HPP) 的研究染色体为中心的HPP (C-HPP)大挑战项目大挑战项目人类蛋白质图书馆人类蛋白质图书馆人类蛋白质组组织 (HUPO)人类蛋白质组项目 (HPP)质谱交互式虚拟环境知识库 (MassIVE-KB)类天文图集 类天文图集 类天文图集缺乏的蛋白质 (MP)neXtProt 蛋白质存在 (PE) 度量表其他非MS PE1 蛋白质.没有特征的蛋白质存在1 (uPE1)更多相关视频
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