肺癌的负担归因于中国的颗粒物污染:从1990年到2019年的流行病学研究
1Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing, Jiangsu Province, China; University College London Great Ormond Street Institute of Child Health, Population, Policy & Practice Research and Teaching Department, London, UK; Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu Province, China.
Public health
|January 17, 2024
概括
颗粒物 (PM2.5) 污染对中国的肺癌负担产生重大影响. 虽然家庭空气污染减少,但环境PM2.5暴露导致肺癌病例增加,特别是在男性和老年人群中.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 肺癌仍然是全球和中国的重大健康问题.
- 暴露于颗粒物 (PM2.5) 是众所周知的各种呼吸道疾病的风险因素,包括肺癌.
- 了解可归因于PM2.5的肺癌负担趋势对于公共卫生干预至关重要.
研究的目的:
- 分析中国的PM2.5污染造成的肺癌的疾病负担.
- 检查从1990年到2019年肺癌残疾调整寿命年 (DALYs) 的时间趋势.
- 调查年龄,周期和队列对与PM2.5.5相关的肺癌DALY的影响.
主要方法:
- 利用了来自2019年中国全球疾病负担研究的数据.
- 采用Joinpoint回归模型来评估肺癌DALY的时间趋势.
- 应用年龄周期队列模型来分析暴露-反应关系.
主要成果:
- 家庭空气污染的肺癌DALY每年下降2.9%,而环境PM2.5污染 (APE) 的DALY每年增加4.7%.
- 肺癌负担 (DALYs) 在男性中高于女性,并且随着年龄的增长而增加.
- 周期和队列效应显著影响了肺癌DALY率,表明所有年龄组的整体上升.
结论:
- 需要有效的策略来减轻中国的PM2.5暴露,特别是来自户外来源的暴露.
- 观察到的性别差异和年龄,周期和队列效应为长期肺癌趋势提供了关键的见解.
- 减少环境PM2.5污染对于制中国日益严重的肺癌负担至关重要.
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