纳米增强免疫疗法:针对免疫抑制瘤微环境
Yuzhi Jin1, Yangyue Huang2, Hui Ren1
1Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China; National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou, 310058, China.
Biomaterials
|January 17, 2024
概括
这篇评论探讨了瘤微环境 (TME),重点是抑制免疫细胞如何影响癌症免疫疗法. 纳米医学为克服当前免疫疗法挑战提供了潜在的解决方案.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 纳米技术纳米技术
背景情况:
- 瘤微环境 (TME) 是一个复杂的系统,支持瘤的形成和进展.
- TME异质性影响免疫疗法反应,将瘤分类为"免疫冷"或"免疫热".
- 关键的抑制性免疫细胞,如巨细胞,髓质衍生抑制细胞和调节性T细胞在瘤发育和转移中起着关键的作用.
研究的目的:
- 审查主要抑制性免疫细胞在TME和瘤发育中的作用.
- 检查针对这些免疫细胞的免疫疗法的临床试验.
- 探索药物与纳米材料的组合,以改善癌症治疗.
主要方法:
- 文献综述侧重于TME中抑制性免疫细胞.
- 对针对免疫细胞的免疫疗法临床试验的分析.
- 研究纳米医学在免疫治疗中的应用.
主要成果:
- 抑制免疫细胞显著影响TME形成和癌症进展.
- 纳米技术提出了减轻免疫疗法的有毒副作用和改善向的策略.
- 将药物与纳米材料结合起来,有望提高治疗效率.
结论:
- 了解免疫疗法,免疫抑制性TME和纳米医学之间的相互作用至关重要.
- 纳米医学具有显著的潜力,可以推进传统免疫疗法.
- 需要进一步的研究来开发更有效的基于纳米医学的癌症免疫疗法.
更多相关视频
09:01Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
366
07:44Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
7.5K
相关概念视频
01:27Tumor Immunotherapy
527
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
527
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
01:27Cytotoxic T Cells-mediated Immune Response
921
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
921