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Updated: Jul 5, 2025

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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调整相互排他性框架,以识别瘤性途径内的驱动突变

Xinjun Wang1, Caroline Kostrzewa1, Allison Reiner1

  • 1Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

American journal of human genetics
|January 17, 2024
PubMed
概括

识别癌症驱动基因对于向治疗至关重要. 一种新的计算方法,MAGPIE,使用相互排他性模式来区分驾驶员和乘客突变,改善癌症基因发现.

关键词:
在RTK-RAS中.驱动器突变 驱动器突变相互排他性的相互排他性瘤性途径的发生.

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