带有介质细胞特征的介质细胞通过形成原生源微环境来增强腹膜传播
Atsuko Yonemura1, Takashi Semba2, Jun Zhang1
1Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan; Gastrointestinal Cancer Biology, International Research Center of Medical Sciences (IRCMS), Kumamoto University, Kumamoto 860-0811, Japan; Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan.
Cell reports
|January 17, 2024
概括
恶性炎中介质细胞通过招募免疫抑制细胞并增强转移,促进胃癌的扩散. 这项研究揭示了它们在创造促进瘤的微环境中的作用,这对于腹膜传播至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 腹膜传播的恶性炎含有多种不同的细胞和分子成分.
- 瘤中瘤微环境尚未完全理解,特别是在胃癌中.
研究的目的:
- 为了全面描述瘤微环境在恶性瘤.
- 在胃癌中确定驱动腹传播的细胞机制.
主要方法:
- 单细胞蛋白质基因分析 单细胞蛋白质基因分析
- 恶性炎的综合蛋白质组分析.
主要成果:
- 在胃癌中观察到免疫效应因子的缺陷和免疫抑制细胞的积累.
- 鉴定出了五种不同的CD45(-) /EpCAM(-) 细胞亚群.
- 在这些亚种群中,具有介质细胞特征的介质细胞被确定为免疫抑制性髓状细胞 (IMC) 招募化学因子的主要来源.
- 介质细胞-介质细胞过渡 (MMT) 诱导的介质细胞表达细胞外基因矩阵 (ECM) 基因,如Tenascin-C (TNC),促进转移性殖民.
结论:
- 亚氏体中介质细胞在培养原始原始微环境方面发挥着关键作用.
- 这些细胞通过调节免疫反应和增强转移,在胃癌中显著促进腹膜扩散.
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