开发和持续释放微粒的实体评估装载着莱沃甲状腺素用于治疗甲状腺功能低下症
Hussam H Alhawari1, Raghad M Abuhamdan2, Majd Alrashdan2
1School of Medicine, The University of Jordan, Amman 11942, Jordan.
Journal of pharmaceutical sciences
|January 17, 2024
概括
这项研究开发了长效的levothyroxine微粒用于甲状腺功能低下症治疗. PLA微粒显示出优异的药物加载和持续释放,为每日口服治疗提供了一个有希望的替代方案.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 内分泌学 在内分泌学.
背景情况:
- 甲状腺功能低下症需要每天口服levothyroxine,它具有可变的吸收和剂量挑战.
- 开发持续释放的注射配方对于改善甲状腺激素替代疗法至关重要.
研究的目的:
- 使用可生物降解的聚合物 (PLGA和PLA) 创建和描述带有levothyroxine的微粒.
- 评估从这些微粒中释放的levothyroxine的体外和体内释放特征.
主要方法:
- 使用PLGA和PLA的乳化溶剂蒸发方法制造了Levothyroxine微粒.
- 分析了微粒子大小,泽塔潜力,药物负载和封装效率.
- 在10天内进行了体外和体内双相释放的研究.
主要成果:
- 无论是PLGA还是PLA微粒,它们都表现出相似的大小 (1.9μm) 和泽塔电位 (-22.0 mV).
- 与PLGA相比,PLA微粒显示药物负载 (6.1%) 和封装效率 (36.8%) 显著提高.
- 在试验室和体内,PLA微粒的药物释放速度较慢,具有两相模式.
结论:
- 含有levothyroxine的聚微粒,特别是用PLA制成的聚微粒,显示出作为长效注射治疗的潜力.
- 这种配方可以克服目前治疗甲状腺功能低下症的口服勒沃西治疗的局限性.
- 进一步的发展可能会导致改善患者的遵守性和甲状腺功能管理.
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