IUPHAR审查:在疼痛研究中导航临床前模型的作用
Seyed Asaad Karimi1, Fatama Tuz Zahra2, Loren J Martin3
1Department of Psychology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada.
Pharmacological research
|January 17, 2024
概括
临床前疼痛研究模型对于理解慢性疼痛机制和开发新疗法至关重要. 本综述考察了炎症和神经病痛的疼痛模型,强调它们在促进缓解疼痛的药物发现中的作用.
科学领域:
- 神经科学和药理学 神经科学和药理学
- 临床前疼痛研究研究
背景情况:
- 慢性疼痛影响全球数百万人,需要对其机制有更深入的了解.
- 临床前模型对于调查疼痛途径和确定治疗点至关重要.
研究的目的:
- 审查慢性疼痛的临床前模型,重点关注炎症和神经病变类型.
- 评估这些模型在开发新型止痛药物的作用.
- 讨论从过去的药物开发挑战和成功中吸取的经验教训.
主要方法:
- 使用已建立的临床前模型探索感觉和疼痛机制.
- 动物研究中的炎症和神经病痛模型的详细分析.
- 对包括生物药物,受体对抗剂和调制剂在内的治疗策略的审查.
主要成果:
- 临床前模型对于研究疼痛机制和测试潜在的候选药物至关重要.
- 从模型中获得的见解为生物药物和受体对抗剂 (例如NMDA,大麻素) 的发展提供了信息.
- 与TRPV1调节和NK-1抗剂的挑战,以及Ziconotide的部分成功,提供了关键的教训.
结论:
- 临床前模型为开发有效的慢性疼痛疗法提供了基础.
- 了解模型的局限性是改善临床前发现转化为临床成功的关键.
- 使用精细的临床前模型进行持续的研究对于减轻慢性疼痛的全球负担至关重要.
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