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Updated: Jul 5, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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精确激活cGAS-STING通路,使用一种新的基于的纳米激动剂来增强免疫检查点阻塞癌症免疫疗法

Yumeng Xing1,2, Ao Peng1, Jianhui Yang1

  • 1School of Pharmacy, Anhui Medical University, Hefei, 230032, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|January 17, 2024
PubMed
概括

一种新的类纳米药物激活cGAS-STING通路并阻断PD-1/PD-L1,增强T细胞抗瘤免疫力. 这种方法为癌症治疗中小分子STING激动剂提供了一个有希望的替代方案.

关键词:
在PD-1/PD-L1封锁中.抗微生物类的抗微生物.cGAS-STING的激活方式癌症免疫疗法免疫疗法多种刺激可以被激活.

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