丸激素治疗的成本效益利用来自男性低丸激素水平的随机对照试验的个体患者数据
Rodolfo Hernández1, Nipun Lakshitha de Silva2,3, Jemma Hudson4
1Health Economics Research Unit, University of Aberdeen, Foresterhill, Aberdeen, UK.
Andrology
|January 17, 2024
概括
激素治疗对75岁以下的男性具有低激素的成本效益很高,但对于年长的男性来说并非如此. 需要进一步的研究来确认老年人群的长期益处和安全性.
科学领域:
- 内分泌学 在内分泌学.
- 卫生经济学 卫生经济学
- 老年病的医生 老年病的医生
背景情况:
- 丸激素疗法是建立在有机性低阴性症的.
- 处方趋势显示,与年龄相关的低丸激素的老年男性使用量增加.
- 在这个人口群体中,安全性和益处的证据有限.
研究的目的:
- 为了评估丸激素治疗与不治疗的成本效益.
- 分析中年和老年男性低丸激素的治疗价值.
- 为了比较不同年龄组的成本和质量调整后的寿命年.
主要方法:
- 使用马尔科夫模型进行10年成本效益分析.
- 包括来自随机对照试验的个体患者元分析数据.
- 对40岁,60岁和75岁的男性进行丸激素治疗与不接受治疗的比较.
主要成果:
- 对的10年过剩成本从每名患者的2306英到3269英不等.
- 在使用贝克抑郁指数数据的75岁以下男性中,丸激素具有成本效益 (<20,000英ICER).
- 75岁以上的男性没有观察到成本效益,特别是假设增加了发病率/死亡率.
结论:
- 丸激素治疗似乎对75岁以下的男性具有低丸激素的成本效益.
- 75岁以上男性的成本效益取决于心血管安全数据.
- 为了得出最终的结论,需要更长期的,可靠的成本效益数据.
相关概念视频
01:20Disorders of the Male Reproductive System
419
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
419
01:52Regression Toward the Mean
6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
129
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
129
01:11Blinding
2.5K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
2.5K
01:12Hazard Ratio
128
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
128