在40岁或以上的艾滋病毒感染者中,他类药物的使用不足
Pei-Ying Wu1, Hsin-Yun Sun2, Yu-Shan Huang2
1Center of Infection Control, National Taiwan University Hospital, Taipei, Taiwan.
概括
许多携带艾滋病毒的人患动脉样硬化心血管疾病 (ASCVD) 的风险很高. 虽然许多人有资格接受他类药物治疗,但很大一部分人没有获得处方,这表明预防性护理存在差距.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 艾滋病毒感染与动脉样硬化心血管疾病 (ASCVD) 的风险增加有关.
- 有效管理ASCVD风险因素对于改善艾滋病毒感染者的长期结果至关重要.
- 目前的指导方针建议对ASCVD风险较高的个体进行他类药物治疗.
研究的目的:
- 为了评估10年的动脉样硬化心血管疾病 (ASCVD) 风险在艾滋病毒阳性个体的队列.
- 根据已确定的风险标准,确定有资格接受他类药物治疗的参与者比例.
- 评估符合条件的艾滋病毒阳性个体中使用他类药物的处方率.
主要方法:
- 从2022年6月到2023年4月,由1629名艾滋病毒阳性参与者参与的前性队列研究.
- 使用经过验证的风险评估工具计算10年ASCVD风险.
- 对他类药物的资格标准和处方模式的分析.
主要成果:
- 大多数参与者 (59.9%) 的10年ASCVD风险低 (<5%).
- 很大一部分患者 (27.0%) 符合他类药物治疗的标准 (风险≥7.5%).
- 在那些有资格服用他类药物的人中,只有38.8%的人被处方治疗,突出显示了治疗差距.
结论:
- 显著的比例的HIV阳性个体表现出高的ASCVD风险,保证预防性干预.
- 在符合条件的艾滋病毒阳性个体中,他类药物治疗的处方量显著不足.
- 解决这种对他类药物处方的差距对于减轻该人口心血管风险至关重要.
相关概念视频
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
664
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
664
Retrovirus Life Cycles
46.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.0K
Pulmonary Tuberculosis I
243
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
243
Sexually Transmitted Infections
315
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
315
Blood Studies for Cardiovascular System III: Serum Lipid Profile
164
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
164
Cholesterol: Significance and Regulation
549
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
549


