压力轴和氧化还原平衡之间的性别特异性相互作用与青少年内化症状和大脑白质微观结构有关
Zoé Schilliger1,2, Yasser Alemán-Gómez3, Mariana Magnus Smith4
1Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Translational psychiatry
|January 17, 2024
概括
女青少年表现出较高的内化症状,与下丘脑-垂体-上腺 (HPA) 轴功能和谷氨 (GSH) 稳态有关,影响大脑白质的发育.
科学领域:
- 神经科学是一个神经科学.
- 青少年心理学 青少年心理学
- 生物化学 生物化学
背景情况:
- 青春期涉及情绪调节系统的成熟,增加了内化障碍的风险,特别是在女性身上.
- 脑下垂体-垂体-上腺 (HPA) 轴功能和还原平衡与内化障碍和情绪调节大脑网络有关.
- 这些因素与大脑成熟过程中的内化症状之间的性别特异性相互作用尚未得到充分研究.
研究的目的:
- 调查青少年内化症状中的性别差异.
- 检查与谷氨 (GSH) - 氧化剂循环恒温和HPA轴功能的关联.
- 确定这些参数与白质微观结构的发展之间的联系.
主要方法:
- 来自普通人口的青少年 (n=69,年龄13-15岁) 的队列研究.
- 评估了内化症状,GSH-过氧化酶 (GPx) 和GSH-减少酶 (Gred) 的活性,以及皮质醇/11-脱氧皮质醇比.
- 分析了与大脑白质微观结构的关联,使用了通用分数异构.
主要成果:
- 女性表现出比男性更高的内化症状,GPx活性和皮质醇/11-脱氧皮质醇比率.
- 皮质醇/11-脱氧皮质醇比率与两性内化症状相关;GPx活性仅在女性中相关.
- 在女性中,GPx活性与白质分数异质性积极相关;HPA轴功能调解了内化症状的性别差异.
结论:
- 在女性青少年中,更高的内化症状与HPA轴功能中的性别差异有关.
- 表明HPA轴功能与女性的GSH恒温之间存在显著的相互作用.
- 这种相互作用与青少年女性大脑白质微观结构的发展有关.
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