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Updated: Jul 5, 2025

Murine Model of CD40-activation of B cells
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Murine Model of CD40-activation of B cells

Published on: March 5, 2010

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BACH2介导的CD28和CD40LG轴有助于T细胞淋巴细胞白血病的发病和进展

Min Feng1, Bailing Zhang2,3,4, Guilan Li1

  • 1Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, 650118, China.

Cell death & disease
|January 17, 2024
PubMed
概括

在T细胞急性淋巴细胞白血病 (T-ALL) 中,BTB和CNC同源性2 (BACH2) 作为瘤抑制剂. 恢复BACH2水平通过抑制CD28和CD40LG信号通路来抑制T-ALL进展和转移.

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T Cell Activation and Clonal Selection01:22

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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