酒精消费与睡眠特征之间的关联:英国生物库的观察性和门德尔随机化研究
Jun-Wei Zheng1,2, Si-Zhi Ai3,4,5, Su-Hua Chang6
1National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, 100191, Beijing, China.
Molecular psychiatry
|January 17, 2024
概括
即使是轻量的酒精消费也与睡眠不良有关,增加了打和晚间时间型的风险. 公共卫生意识对于酒精饮料至关重要.
科学领域:
- 睡眠科学 睡眠科学
- 营养精神病学 营养精神病学
- 遗传流行病学遗传流行病学
背景情况:
- 众所周知,过度饮酒会影响睡眠质量.
- 轻度至中度饮酒对各种睡眠特征的影响尚不清楚.
- 在一般人群中,酒精摄入量和睡眠障碍之间的因果关系尚未得到充分确立.
研究的目的:
- 为了研究酒精消费与多种睡眠特征之间的联系.
- 使用孟德尔随机化 (MR) 确定酒精摄入量和睡眠障碍之间的因果关系.
主要方法:
- 使用观察和门德尔随机化 (MR) 设计与英国生物库 (UKB) 数据.
- 包括383,357名UKB参与者的遗传和临床数据.
- 使用国家健康和营养检查调查 (NHANES) 数据进行外部验证的发现.
主要成果:
- 酒精消费与所有分析的睡眠特征 (失眠,打,睡眠时间,时间型) 有显著的关联.
- 增加的酒精摄入量与打和晚间时间型线性相关.
- 基因预测的酒精消费与更高的打风险和晚间时间型的因果关系.
结论:
- 即使低水平的酒精消费也会对睡眠健康产生负面影响.
- 酒精摄入量与打风险增加和晚间时间型的发展有关.
- 公共卫生信息应该强调酒精对睡眠的不利影响.
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