通过非正规的皮质 - 杏仁体通道进行自上而下的飞行控制
Chandrashekhar D Borkar1,2, Claire E Stelly1,2,3, Xin Fu2,4
1Department of Psychology, Tulane University, New Orleans, LA, USA.
Nature
|January 17, 2024
概括
研究人员发现了一条新的大脑通路,控制着像结和飞行这样的防御行为. 这种背部脚 (DP) 到中枢桃体 (CeA) 电路对于高强度威胁反应和避免至关重要.
科学领域:
- 神经科学是一个神经科学.
- 行为生物学 行为生物学
- 前额叶皮层研究研究
背景情况:
- 适当的威胁反应对于生存至关重要.
- 失调的防御反应与精神疾病如PTSD和恐慌症有关.
- 中枢桃体 (CeA) 中的神经回路控制威胁行为,但CeA激发高强度反应的来源尚不清楚.
研究的目的:
- 为了确定CeA中神经元激发的来源.
- 要描述从背部脚 (DP) 前额叶皮层到CeA的以前未知的投射.
- 阐明这种途径在防御性行为中的作用.
主要方法:
- 神经解剖学绘制地图
- 在体内摄取的成像.
- 功能性操纵是一种功能性操纵.
- 电子生理学 电子生理学
- 对于结和飞行的行为范式.
主要成果:
- 确定了一种从DP前额叶皮质到中枢CeA的新型谷氨酸投射.
- DP-to-CeA神经元被高强度的威胁激活,这种方式取决于环境.
- 从DP到CeA的路径对于回避和飞行行为来说既必要又足够.
- DP神经元突触到中间的CeA神经元,向中脑飞行中心投射.
结论:
- 从DP皮质到CeA的非法典上下路径调节了防御反应.
- 这条路径在避免和逃跑中起着关键作用.
- 了解这种电路为威胁和恐惧反应的神经生物学提供了新的见解.
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