应用的淋巴激素总剂量与非PCOS患者的活产率之间的非线性关系:一个回顾性队列研究
Xiaoyuan Xu1, Aimin Yang1, Yan Han1
1Hebei Key Laboratory of Infertility and Genetics, Department of Reproductive Medicine, Hebei Clinical Research Center for Birth Defects, Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.
Scientific reports
|January 17, 2024
概括
较高的卵泡刺激激素 (FSH) 剂量可能会降低接受试管婴儿/ICSI的妇女的活产率 (LBR). 确定了1410 IUFSH的门值,超出此门后,LBRs下降,特别是在老年患者中.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
背景情况:
- 在受控排卵刺激中,卵泡刺激激素 (FSH) 剂量与活产率 (LBRs) 之间的关系仍然存在争议.
- 之前的研究对FSH剂量对怀孕结果的影响产生了相互矛盾的结果.
- 在FSH剂量和LBRs之间的非线性关联尚未得到广泛的探索.
研究的目的:
- 在接受试管婴儿/ICSI的非PCOS人群中研究总FSH剂量和LBR之间的关联.
- 探索潜在的非线性关系,并确定FSH剂量对LBRs的任何值效应.
- 检查年龄如何改变FSH剂量与LBRs之间的关系.
主要方法:
- 在2014年12月至2019年12月期间,对11645名接受试管婴儿/ICSI治疗的患者进行了回顾性队列研究.
- 使用多变量回归分析来评估总FSH剂量与LBRs之间的关联.
- 应用了两部分线性回归模型来分析非线性关系和值效应.
主要成果:
- 观察到一个显著的值效应:当FSH剂量低于1410 IU (OR 1.55) 时,LBRs增加,但在超过这个值的剂量时 (OR 0.94) 降低.
- 总FSH剂量显示出与LBRs的非线性关联.
- 根据患者年龄,FSH剂量与LBR之间的关系有显著的变化,老年患者表现出更明显的负面关联.
结论:
- 在受控排卵刺激中使用的FSH总剂量对接受IVF/ICSI的非PCOS患者的LBR有非线性影响.
- 存在一个最佳的FSH剂量值 (大约1410 IU),超过这个值后,增加剂量与LBRs的减少有关.
- 年龄是影响FSH剂量-LBR关系的关键因素,需要个性化治疗方案.
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