改善乳腺癌患者口服内分泌疗法坚持性的干预措施
Sourab Ganna1, Sama Rahimi2, Anh Lu3
1Department of Pharmaceutical Health Outcomes and Policy, University of Houston College of Pharmacy, Houston, TX, 77204, USA.
Journal of cancer survivorship : research and practice
|January 17, 2024
概括
在激素受体阳性乳腺癌 (HR+BC) 患者中改善口服内分泌疗法 (OET) 的坚持是至关重要的. 包括技术和沟通策略在内的新型干预措施,在提高药物坚持和持续性方面表现有前途.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 口服内分泌疗法 (OET) 是预防和治疗激素受体阳性乳腺癌 (HR + BC) 的基石.
- 尽管已证明有好处,但患者对OET的不良坚持仍然是一个重大挑战,影响治疗疗效.
- 解决坚持障碍对于改善HR+BC幸存者的治疗结果至关重要.
研究的目的:
- 系统地审查文献,并确定有效的干预措施,以改善HR+BC患者的OET遵守.
- 综合技术,基于文本和口头沟通干预的发现.
- 突出需要以患者为中心的策略在OET遵守.
主要方法:
- 系统的文献审查,遵循PRISMA框架.
- 在主要数据库 (PubMed,SCOPUS,EMBASE,Cochrane,Web of Science) 进行的搜索.
- 包括使用OET (AI,SERMs) 的患者的纵向研究,以测量坚持,持久性或可接受性.
主要成果:
- 十项研究符合纳入标准,主要涉及早期HR+BC患者.
- 技术干预 (2/2研究) 和文本通信 (2/3研究) 在OET坚持/坚持方面显示出显著的改善.
- 口头沟通干预 (3/5项研究) 也表明对坚持和/或持久性的积极影响.
结论:
- 目前的干预措施显示出潜力,但往往解决单一障碍,需要结合方法.
- 开发以患者为中心的多面策略对于改善所有HR+BC患者的OET遵守是必不可少的.
- 新型干预措施可以提高OET的坚持,强调量身定制的患者支持的重要性.
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