精子MD:表达精子成熟的表达图谱
Yifan Li1, Qianying Li2, Lvying Wu2
1School of Informatics, National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China.
BMC bioinformatics
|January 17, 2024
概括
男性的不孕不育与精子成熟的受损有关. 一个新的数据库,SperMD,集成多omics数据,提供一个全面的分子视图,帮助研究和男性不孕症的潜在疗法.
科学领域:
- 生殖生物学 生殖生物学
- 生物信息学是一种生物信息学.
- 基因组学就是基因组学.
背景情况:
- 男性不孕不育是一个重要的全球健康问题,通常源于受损的精子成熟.
- 目前关于精子成熟的研究受到缺乏综合分子数据的限制.
- 对精子成熟的全面理解需要一个全球性的分子视角.
研究的目的:
- 建立一个集中式数据库,SperMD,整合多omics数据用于精子成熟研究.
- 提供精子成熟的全景分子视图,包括转录,转化和代谢变化.
- 促进探索新型基因功能,并确定用于男性不孕症诊断和治疗的生物标志物.
主要方法:
- 整合异质的多基因数据,包括转录组,蛋白质组和代谢组.
- 开发精子成熟数据库 (SperMD) 提供用户友好的网络服务.
- 包括来自各种生物背景的数据,如流行性微环境和病理状态.
主要成果:
- SperMD为精子成熟提供了一个全面的资源,整合了170个转录组,91个蛋白质组和5个代谢组.
- 该数据库涵盖了精子成熟的关键方面,包括组织成分,细胞成分和病理状况.
- 网络服务使得有效的数据检索和跨物种分子比较 (人类和老鼠) 成为可能.
结论:
- 精子MD作为一个有价值的,全面的资源,用于系统研究的精子成熟.
- 数据库提供了全景的分子视图,对于理解精子如何获得充分的生殖能力至关重要.
- SperMD将有助于优先考虑生物标志物和治疗目标,以准确诊断和治疗男性不孕症.
相关概念视频
01:15Sperm Transport
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The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
The maturation phase occurs in the epididymis, where sperm...
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01:41Spermatogenesis
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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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01:22Sperm Structure and Semen Composition
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During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
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01:19Testes: Gross Anatomy
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The testes, also known as testicles, are the male gonads. They are housed within the scrotum, a sac-like structure located beneath the penis. The scrotum's primary role is to regulate the temperature of the testes, which is crucial for sperm production.
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
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01:27Testes: Histology
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A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
The spermatogenic cells, responsible for producing sperm, are...
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01:16Accessory Glands of the Male Reproductive System
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The accessory ducts involved in sperm maturation and transportation include the epididymides, vasa deferentia, ejaculatory ducts, and urethra. These ducts play a critical role in the maturation, storage, and transportation of sperm from the testes to the urethra, where it is then released during ejaculation.
The epididymis is a small, comma-shaped organ located at the back of each testicle. The epididymis can be divided into three main parts: the head, body, and tail. The head of the epididymis...
The epididymis is a small, comma-shaped organ located at the back of each testicle. The epididymis can be divided into three main parts: the head, body, and tail. The head of the epididymis...
1.6K