CircNetVis:一个交互式 Web 应用程序,用于可视化循环 RNA 的交互网络
Thi-Hau Nguyen1, Ha-Nam Nguyen1,2, Trung Nghia Vu3
1University of Engineering and Technology, Vietnam National University in Hanoi, Hanoi, 84024, Vietnam.
BMC bioinformatics
|January 17, 2024
概括
CircNetVis是一个新的网络工具,用于可视化循环RNA (circRNA) 相互作用. 它通过一个易于使用的在线平台帮助研究人员探索circRNA网络,包括未知的网络.
科学领域:
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
- 分子生物学分子生物学
背景情况:
- 循环RNAs (circRNAs) 起着至关重要的作用,理解它们的相互作用是它们功能分析的关键.
- 现有的circRNA相互作用可视化工具仅限于已知的circRNA,需要复杂的安装.
- 需要一个用户友好的Web应用程序来进行交互式circRNA网络探索.
研究的目的:
- 开发一个交互式Web应用程序,CircNetVis,用于分析人类和老鼠circRNA相互作用.
- 为可视化circRNA网络提供一个用户友好的平台,包括以前未知的circRNA网络.
- 为了促进研究circRNAs,microRNAs,mRNAs和RNA结合蛋白之间的复杂相互作用.
主要方法:
- CircNetVis通过ID (CircBase),基因组坐标或FASTA序列接受circRNA数据.
- 该工具集成了多个交互网络进行全面分析.
- 它作为一个使用R-shiny实现的Web应用程序来实现可访问性.
主要成果:
- CircNetVis允许交互可视化和探索circRNA交互网络.
- 用户可以分析涉及已知和未知的circRNAs的相互作用.
- 该应用程序支持多种输入格式,并生成可下载结果的交互图表.
结论:
- 对于研究circRNA功能的研究人员来说,CircNetVis提供了一个有价值的,可访问的资源.
- 该网络应用程序简化了circRNA相互作用的分析,克服了现有工具的局限性.
- 它促进了对circRNAs在生物过程中的作用的更广泛的研究.
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