儿童 系统性狼与红血性狼相关的胰腺炎
Dan Zhang1, Jianming Lai2, Gaixiu Su1
1Department of Rheumatology and Immunology, Children's Hospital of Capital Institute of Paediatrics, No.2 Yabao Road, Chaoyang District, Beijing, 100020, China.
Arthritis research & therapy
|January 17, 2024
概括
患有全身性红斑狼 (cSLE) 的儿童患有胰腺炎的死亡率很高. 早期识别雷诺症和脏梗塞等症状对于及时干预和改善结果至关重要.
科学领域:
- 儿科 儿科 儿科
- 类风湿病学 类风湿病学
- 胃肠病学 胃肠病学
背景情况:
- 儿科系统性红斑狼 (cSLE) 是一种复杂的自身免疫性疾病,具有多样化的临床表现.
- 胰腺炎是cSLE的严重并发症,影响患者的预后,需要具体的诊断和治疗考虑.
研究的目的:
- 确定与cSLE相关的胰腺炎相关的关键临床特征和预后因素.
- 改善对被诊断患有cSLE相关胰腺炎的儿童的早期识别和管理策略.
主要方法:
- 在2016年至2021年期间,对12名被诊断患有cSLE相关胰腺炎的儿科患者进行了回顾性分析.
- 临床数据,疾病活性评分 (SLEDAI-2K),实验室标记和治疗方式在病例和对照组之间进行了比较.
主要成果:
- 患有cSLE相关胰腺炎的患者表现出明显更高的疾病活性 (SLEDAI-2K) 和更高的腹痛,吐,多流液,雷诺现象 (RP),脏梗塞和巨细胞激活综合征 (MAS) 的患病率.
- 血清费里丁,ALT,AST,LDH,粉酶和24小时尿蛋白的升高,以及血小板数量的减少,在各组之间有显著差异.
- 治疗通常涉及密集治疗,包括甲基前尼索隆脉冲,环胺脉冲和治疗性血交换.
结论:
- 与cSLE相关的胰腺炎具有很高的死亡率.
- 临床指标,如RP,脏病发作,外流和MAS,应提醒临床医生,在cSLE患者中潜在的胰腺炎.
- 及时治疗潜在的cSLE对于改善相关胰腺炎的预后至关重要.
相关概念视频
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01:27Acute Pancreatitis I: Introduction
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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
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Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
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