对下体负压的同情反应的性别差异
Caitlin P Jarrard, Joseph C Watso, Whitley C Atkins
1Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX.
Medicine and science in sports and exercise
|January 18, 2024
概括
与男性相比,女性对模拟出血的耐受性较低,血压降低和肌肉交感神经活动 (MSNA) 较低. 这表明在低血压期间自主心血管调节的性别差异.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统的调节规则
- 在生理学的性别差异.
背景情况:
- 创伤引起的出血是医院前环境中死亡的重要原因.
- 与男性相比,女性对模拟出血 (中央低血压) 的耐受性较低.
- 在低血压反应中基于性别的差异背后的机制仍然不清楚.
研究的目的:
- 为了研究和比较自主性心血管反应在性别之间的中央低血压期间.
- 为了测试女性在模拟出血期间耐受性较低和肌肉交感神经活动 (MSNA) 减弱的假设.
主要方法:
- 对17名女性和19名男性 (19-45岁) 的数据进行了回顾性分析.
- 利用渐进的下体负压 (LBNP) 协议来模拟出血,直到昏迷前.
- 测量了连续的MSNA和节拍对节拍的血液动力学变量,比较了特定LBNP阶段的反应和相对容忍水平.
主要成果:
- 女性对中央低血压的耐受性明显较低 (561比894分·mmHg).
- 雌性在 -40和 -50 mmHg LBNP 时表现出较低的透析血压.
- 相对于耐受性,女性的MSNA爆发频率降低,总血管导电率降低.
结论:
- 与男性相比,女性对中央低血压症的耐受性较低.
- 这种降低的耐受性与更低的透析血压和女性减弱的MSNA反应有关.
- 研究结果强调了在低血压压力期间自主心血管控制的基于性别的差异.
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