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来自Wikstroemia lungtzeensis的塞斯基烯具有抗神经炎症作用

Yan-Ping Zhang¹, Ying-Jie Wang¹, Yan Mi²

¹Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.

Journal of Asian natural products research

|January 18, 2024

概括

Wikstroemia lungtzeensis产生了具有抗神经炎症作用的新型胡卜素类型基. 六种化合物抑制了氧化的产生,显示了治疗神经退行性疾病的潜力.

科学领域:

植物化学植物化学
神经科学是一个神经科学.
药理学药理学是指药理学的学科.

背景情况:

神经炎症是神经退行性疾病的一个关键因素.
Wikstroemia lungtzeensis是一种具有潜在药用功能的植物.
对W. lungtzeensis的抗神经炎症活性缺乏植物化学研究.

研究的目的:

为了隔离和描述来自W. lungtzeensis的化合物.
评估分离化合物的抗神经炎症活性.
为了确定神经退行性疾病的潜在治疗剂.

主要方法:

使用光谱技术进行植物化学调查 (NMR,MS,ECD).
从W. lungtzeensis的乙烯酸乙烯提取物中分离化合物.
在体外抗神经炎症测定使用脂聚糖刺激的BV-2细胞来测量氧化的产生.

主要成果:

分离了三种新的胡卜素类型的甲 (excoecafolinols C-E) 和九种已知的衍生物.
六种化合物 (1, 2, 4, 7, 11, 12) 显著抑制了氧化的产生.
卡罗坦类型的基 (1, 2, 4) 显示出强烈的活性,IC50值在10.48~49.41μM之间.

结论:

Wikstroemia lungtzeensis含有具有抗神经炎症特性的生物活性甲.
卡洛类型的基烯是W. lungtzeensis的主要活性成分.
这些化合物显示出作为神经退行性疾病治疗剂的前景.

关键词:

维克斯特罗米亚肺炎病毒 (Wikstroemia lungtzeensis) 是一种抗神经炎症活动.卡洛类型的六二烯.

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