非严重的急性呼吸道冠状病毒2 (SARS-CoV-2) 呼吸道病毒的循环值动态
Selina Ehrenzeller1,2,3,4, Rebecca Zaffini5, Nicole D Pecora5
1Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, United States.
Infection control and hospital epidemiology
|January 18, 2024
概括
非SARS-CoV-2呼吸道病毒的循环值 (Ct) 通常遵循与SARS-CoV-2类似的时间模式. 这些发现表明Ct值可能有助于管理其他呼吸道感染.
科学领域:
- 临床病毒学 临床病毒学
- 传染性疾病 传染性疾病
- 呼吸系统的病原体
背景情况:
- 严重急性呼吸道冠状病毒2 (SARS-CoV-2) 周期值 (Ct) 用于估计病毒载量并为临床决策提供信息.
- 对非SARS-CoV-2呼吸道病毒的Ct值的实用性仍然不太清楚.
研究的目的:
- 对常见的非SARS-CoV-2呼吸道病毒的Ct值的时间变化进行表征.
- 评估Ct值在治疗这些感染中的潜在作用.
主要方法:
- 对于流感,RSV,偏流感,HMPV,鼻膜病毒或腺病毒呈阳性PCR的成年患者进行了回顾性队列研究.
- 对Ct值进行分析,并与症状出现后的几天进行绘图.
- 基于免疫抑制和并发症的Ct值变化的评估.
主要成果:
- 分析了六种不同的呼吸道病毒的1863个阳性样本.
- 大多数病毒在症状出现时显示Ct值在25-30左右,在前1-3天下降,并在一周后增加 (≥30).
- 随着时间的推移,犀牛病毒表现出更高和更稳定的CT值;免疫功能低下状态和CT值进展之间没有发现关联.
结论:
- 流感,RSV和其他非SARS-CoV-2病毒的时间Ct值模式与SARS-CoV-2病毒相似.
- 需要进一步的研究来将Ct值与非SARS-CoV-2病毒的病毒活力,传播能力和治疗反应相关联.
- 对于其他呼吸道病毒,CT值可能会被纳入临床管理和隔离决策.
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