博尔丁:对具有多功能生物和药理潜力的生物活性化合物的叙述性审查
Deepak Lamba1, Durgesh Kumar Dwivedi2, Monu Yadav3
1Central Council for Research in Ayurvedic Sciences, Janakpuri, New Delhi, India.
Journal of complementary & integrative medicine
|January 18, 2024
概括
博尔丁是来自智利博尔多树的化合物,具有广泛的健康益处,包括抗氧化和抗炎作用. 进一步的研究可能会导致针对各种疾病的新药开发.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
- 药用植物学 医学植物学
背景情况:
- 博尔丁 (Boldine) 是一种生物活性阿波芬类化合物,来自智利的博尔多树 (Peumus boldus).
- 广泛的临床前证据支持boldine在一系列疾病中的有益作用.
- 卢米斯金TM是一种商业化皮肤亮化配方,含有boldine衍生物Dicetyl boldine.
研究的目的:
- 系统地审查和更新有关Peumus boldus及其主要生物活性化合物boldine的信息.
- 探索近期在boldine的药理动力学,毒理学和药理活动方面的进展.
- 为了阐明大丁的健康益处背后的分子机制.
主要方法:
- 在科学数据库中进行系统的文献搜索 (PubMed,SciFinder,科学网,谷歌学者,Scopus).
- 关于boldine的作用和机制的临床前和临床研究的审查.
- 对药理动力学和毒理学数据的分析.
主要成果:
- 博尔丁表现出广泛的药理作用,包括抗氧化,肝保护,抗动脉样硬化,抗糖尿病,止痛,抗炎,神经保护和抗癌活动.
- 这些效应通过调节各种生物途径来调节,例如抗氧化剂参数,炎症标志物,亡和神经递质系统.
- 博尔丁在面部黑色素瘤的临床试验中表现有前途,并作为儿科尿路结石石透症的辅助疗法.
结论:
- 博尔丁具有多功能药理性质,具有潜在的治疗应用.
- 它调节多样化的生物网络的能力凸显了它作为天然生物活性化合物的重要性.
- 博尔丁对未来的药物开发具有前景,适用于多种适应症.
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