增加的光无机酸盐抑制了5/6个腎切除的老鼠的肠道Zn吸收
Yosuke Okumura1, Kotaro Abe1, Shoko Sakai1
1Department of Clinical Nutrition and Food Management, Tokushima University Graduate School of Medical Nutrition, Tokushima, Japan.
American journal of physiology. Renal physiology
|January 18, 2024
概括
在慢性病 (CKD) 中,肠道中高酸盐水平会损害的吸收,导致水平较低. 管理酸盐水平可能有助于治疗CKD患者的缺乏症.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 慢性病 (CKD) 与低血症 (低水平) 有关.
- 在CKD中,肠道吸收受损,但根本机制尚未完全理解.
- 低血可以加剧CKD的进展.
研究的目的:
- 在CKD的老鼠模型中研究肠道吸收受损的机制.
- 评估酸盐在CKD中吸收不良中的作用.
主要方法:
- 通过5/6腎切除 (5/6Nx) 建立了一种CKD的老鼠模型.
- 通过测量血度-时间曲线 (iAUC) 下的增量面积来评估肠道吸收.
- 测量了载体ZIP4的表达,以及血清和肠道光中的无机酸盐 (Pi) 水平.
- 在体外实验中评估了Pi对溶解度的影响.
- 评估了饮食中的Pi限制和Pi结合剂对CKD大鼠的低血的影响.
主要成果:
- 与对照组相比,5/6 Nx大鼠的吸收率 (iAUC) 较低,尽管ZIP4表达增加.
- 在5/6Nx大鼠的血清和肠道光线中发现了高的无机酸盐 (Pi) 水平.
- 在正常大鼠中,肠内内Pi的剂量依赖性降低了的吸收.
- 增加的Pi度在体外降低了的溶解度.
- 饮食Pi限制改善了5/6Nx大鼠的低血.
结论:
- 肠道光线Pi的升高有助于CKD中的吸收不良和低血症.
- 酸盐通过形成不溶性复合物来干扰的吸收,独立于ZIP4输送体表达.
- 通过饮食限制Pi或Pi结合剂来管理高酸血症可能是CKD患者低血症的治疗策略.
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