急性缺血性中风后的脉压水平与早期的神经系统恶化有关
Pu Lv1, Linwei Zhang2, Xin Chen1
1Department of Geriatrics, China-Japan Friendship Hospital, Beijing 100029, P.R. China.
Experimental and therapeutic medicine
|January 18, 2024
概括
在急性缺血性中风期间的高脉压变化与早期神经系统恶化 (END) 有关. 监测脉压力可能有助于预测中风患者的不良结果.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
- 临床研究 临床研究
背景情况:
- 早期神经系统恶化 (END) 是急性缺血性中风患者的显著负面结果.
- 血压的变化是导致END发展的潜在因素.
研究的目的:
- 为了研究血压变化和急性缺血性中风患者的END发生之间的关联.
- 为了确定特定的血压参数,可以预测EIND.
主要方法:
- 对286名急性缺血性中风患者进行前性观察性研究,这些患者在发病后24小时内住院.
- 在中风发作后72小时内进行24小时的门诊血压监测.
- 多变量逻辑回归分析以评估血压参数和END之间的关系,调整混因素.
主要成果:
- 在286名患者中,64名患者 (22.3%) 经历了END.
- 在 END 组中观察到更高的24小时平均脉冲压 (24-h PPMEAN) 和白天平均脉冲压 (Day PPMEAN).
- 24小时PPMEAN (OR,1.08;P=0.02) 和白天PPMEAN (OR,1.20;P=0.04) 两者都与END有显著的关联.
结论:
- 缺血性中风急性阶段的脉冲压变化在END的发展中起着重要作用.
- 升高的脉压水平可能成为中风患者恶化的预测因素.
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