针对抗生素耐药微生物的新型候选药物:一篇综述
Jing-Sheng Lim1, Yoke-Yen Chai1, Wei-Xin Ser1
1School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia.
Iranian journal of basic medical sciences
|January 18, 2024
概括
抗生素耐药性是一个日益增长的全球威胁. 这篇综述强调了新型药物和正在进行的针对优先病原体的研究,如耐卡巴胺细菌和耐甲林黄金葡萄球菌.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素耐药性是一个关键的全球健康挑战,导致治疗失败.
- 世界卫生组织已经确定了需要紧急关注的五个优先病原体群.
- 这些包括耐卡巴胺的Acinetobacter baumannii,Pseudomonas aeruginosa,Enterobacteriaceae,耐万科胺的Enterococcus faecium,以及耐甲林/万科胺的Staphylococcus aureus.
研究的目的:
- 审查世卫组织优先病原体的耐药性机制.
- 识别和总结新的候选药物和正在进行的研究,以对抗这些耐药细菌.
主要方法:
- 关于抗生素耐药机制的当前研究的文献综述.
- 对新药候选药物的体外,体内和临床试验数据的分析.
- 探索用于识别新抗菌剂的计算方法.
主要成果:
- 几种新型候选药物显示出对抗抗卡巴胺耐药细菌的前景 (例如,LCB10-0200,阿普拉米辛,埃拉瓦环素).
- 针对Enterobacteriaceae的候选药物包括LysSAP-26, cefiderocol和等离子素.
- 像TNP-209和Debio 1450这样的药物正在分别对E. faecium和S. aureus进行研究.
结论:
- 新型治疗剂正在出现,以挑战多药耐药性病原体.
- 持续的研究,包括体外,体内和临床研究,至关重要.
- 需要对小分子和现有疗法进行进一步的研究,以充分了解它们的潜力和有效性.
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