使用全身EXPLORER PET进行F-florbetaben的非侵入性量化
Emily N Holy1,2, Elizabeth Li2, Anjan Bhattarai1,2
1Department of Neurology, University of California (UC) Davis Health.
Research square
|January 18, 2024
概括
这项研究表明,使用18F-florbetaben进行全身PET成像,可以使用从大动脉获得的图像导入函数进行大脑粉样蛋白沉积的非侵入性量化,从而简化了阿尔茨海默病的研究.
科学领域:
- 神经成像是一种神经成像.
- 核医学是一种核医学.
- 放射化学 放射化学是指辐射化学.
背景情况:
- 使用18F-florbetaben PET量化大脑粉样沉积对于阿尔茨海默病的研究和临床实践至关重要.
- 传统方法需要侵入性动脉血液采样,限制了更广泛的应用.
- 全身PET扫描仪提供动态全身成像功能.
结论:
- 使用18F-florbetaben PET与大动脉衍生的IDIFs进行脑粉样蛋白的非侵入性量化是可行的.
- 在动态分布体积参数和BPnd.之间观察到很高的一致性.
- 这种方法简化了对老年人群的粉样蛋白负担评估的定量PET成像.
![Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62460.jpg&w=3840&q=50)
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